Hi there this is Marcel the author of the new sandbox environment, isolated-vm.
I think what you're seeing here is a tailcall optimization bug in v8. Essentially what happens here is sometimes v8 will generate infinite loops which cannot be stopped, this causes isolated-vm to panic. You can find the original v8 bug report here v8 issue #6933. The fix will be included in the next nodejs release, v8.10.0, but I don't know when that will be released.
In the meantime I've ported the fix to a branch on github: tailcall-backport. This branch is the nodejs v8.9.4 release but with this commit applied on top. I believe the Screeps guys are running this fix on the PTR as well. So please give that version of nodejs a try and see if it resolves this issue.